My Philosophy has always been; get the best single gpu card you can afford, and fill out the blanks with the rest of your cash.
Better for drivers, better for stability, scale is always 1:1 (duh), no bother with profiles and compatibility. Less issues on a whole.
If someone must, MUST buy more than one... get 2x of the best cards available IF you MUST. (don't cry to me when things don't play as well as you thought or you get problems. bit harsh ? I tend to fix very best of mates' computers, family and hot chicks. if you don't fit in that category you got no chance)
Buying 3 - you're wasting cash you could spend on 1 (if you don't use the best single gpu x3)
AND if you're buying 4x of the best single gpu available - AND can afford it - knock yourself out. Why the hell not, you've obviously got the cash - BUT I will chastise you if you have anything less than the very best in 30"+ monitors, as, again, you're wasting cash.
I do that palm to face thing when people buy more than 1 card that isn't the best single gpu - but hey, each to their own.