At the moment I'm running
Focusrite Saffire Pro 24 4 in 6 out Firewire Interface
Oldschool Marantz PM-25 Amp (Was using a Samson Servo 170 but being a power amp it lacks the input flexibility of the Marantz)
Spirit Absolute 2 Monitors
Also use Samson reference and Sony Hi-Fi cans for headphone monitoring.
I still miss my Altec Lansing ADA885 4.1 set, they were awesome and the sub was so good, but I had to chuck them after the PSU caught fire for the third time and obliterated most of its PCB.
Still for sound thats true to the source and home recording it's hard to knock my setup for the money! Would love to have a sub again for those Drum n Bass moments, but the Absolute 2's are handling bass admirably for now. Must be the 6.5" woofers (one of which blew a hole in itself, but I fixed it with rizla and glue).