Most ITX cases I have seen only have a dual slot setup which means the Titan Z is out of the picture and the AIO on the R9 295 X2 could potentially cause internal space issues case wise.
You would be looking at a Ti vs a Titan Black basically as AMD do not have any true dual slot rivals to either of those cards. Don't bother referencing the R9 295 X2 as its a dual chip card and thus not directly comparable to either the Ti or Titan Black.
A mate of mine had one of those boards and I swear a micro ATX board had more features, Felt really cheap for how much it cost.
Same with the Kingpin card, A work mate of mine has it and while it performs nicely it feels cheap in your hands and looks cheap and nasty, Well to my eyes anyway.