How much is it? You need to bear the following in mind.
GTX 480 is hot. Very very hot. Also guzzles down power. You will have a very hard time taming it. I haven't read a review but the cooler does look decent.
Then consider...
A pair of 460s in SLI will beat a 480. A pair of 465 TF in SLI will beat a pair of 460 in SLI.
In SLI you can expect an 85% increase over a single card. Best part? when SLI is inactive (IE you're not gaming) the second card downclocks and volts to pretty much nothing. Meaning heat, noise and power draw are considerably less than running a 480 *all* the time. The 480 is also slower. So, unless the 480 works out cheaper than either SLI option? then there's utterly no reason upon earth why you should get a 480 dude.
SLI and Crossfire absolutely rock the house now (on dual cards) and are supported pretty much in everything. SLI can be a pain because it's driver dependant, but, Nvidia are on the ball with it and you may have a week wait when a new game comes out to get full scaling and speeds.
Crossfire scales in everything but sometimes needs a profile. Incase you were wondering what a profile is? it's incredibly simple. It's a tiny document that tells the cards what to do. There are a few methods of scaling and it simply tells the cards how to go about it. Default scaling does it in a certain way but this doesn't work well with all games. The profiles sort that out.
So with the 480? I would say it's close to being an absolute no dude. A pair of 460s seem to be much cheaper worldwide and will pee in the 480's cornflakes all day, every day.
And depending on the price the 465s will do more of the same, only even better.