My grandads pc uses a AMD APU, with a Nvidia GTX680 and the only AMD drivers installed on his pc are for the motherboard and cpu.
The Graphics portion of the cpu is turned off in the bios, to avoid any driver conflicts and he is playing games just fine, still need to get him a copy of Battlefield 4 yet to really put his pc under some pressure, to see how the cpu copes with it.
You should be fine with a Nvidia card but just remember to turn off the cpu based graphics in the bios and remove the AMD graphics drivers.