Hi,
I added 2x8gb modules to my existing 2x4gb set up and it's working fine. There were some issues however...
The 8gb modules are 10-10-10-27 timings whereas the 4gb modules are 9-9-9-24. You'd expect the BIOS to correctly drop to the lowest common denominator speed right? Nope. The XMS Memory Profile thing on my ASUS P8Z68-V Pro decided to run at the tigher timings - causing instability.
To fix this I simply manually entered the memory timings and it's been behaving well since.
Adding an uneven number of modules, so just the extra 8 the OP mentions, would of course mean you'd be unable to run in dual channel mode - effectively HALFING your bandwidth. Depending on what you're doing this might not be an issue for you - often having MORE ram is preferable to faster ram, as ram is pretty fast anyway. I'd expect running at half speed to be readily noticable in benchmarking apps that take into account memory speed, but in day to day use the impact should be minimal. Doubless there are specific titles that really like faster ram, but I'd not expect it to make anything unplayable.
My advice would be to do it once and do it right, i.e. either get yourself another 2x4gb kit or go for it with a 2x8gb kit if you really need that much ram. I have a total of 24gb ram myself now, but then I play around with Ram Drives a lot so 10 - 16gb of that is used by the drive.
On a 64 bit OS I'd say that 8gb Ram is a very good number for a gamer - I have systems with just 4gb and they struggle at times with certain titles.
Best of luck, whatever you decide.
Scoob.