Crossfire, I have found, is a bit wonky at times. There are games it doesn't work well with. I cannot get it to play nicely with GTA 5 at all. There are games like Euro Truck Sim 2, that do not have predefined profiles, that with a bit of tweaking, I have found settings to work for them.
That said, I do not own either Fallout 4 or the new Star Wars, so I cannot confirm nor deny any crossfire issues with those games.