EDIT: Well, I was replying to another post but it seems to have been deleted!!
PSU?
Overclocking will pull significantly more power, as my own recent testing using a wall-plug power meter have proven. Did you not say thought that you also get instabilities at stock?
If you're not stable at stock, then overclocking will potential just exagerate the issue.
I would pop the system back to stock, with the GPU at stock too & test. Then re-apply the CPU overclock - which I assume was previously stable prior to fitting the 7950 - and test again. I reverted my whole system to stock when I had some weirdness with a GPU overclock - it turned out to be a driver issue between the latest NV beta (at the time) and Skyrim, no other tiltle nor benchmark nor stress tool had any issues what so ever. My point being, I eliminated my CPU overclock from the list, so to speak.
Just some comments on how I test stability...
I start off with 3D Mark Vantage usually, this has proven to be a good, balanced test and can highlight both CPU and GPU instabilities. I then often follow up with Heaven 3.0, as that's fairly heavy on the GPU.
Next I get a bit harsher, I use IBT with AVX extensions for CPU stress test / stability checking, it's the hardest your CPU will ever be pushed. If it's ok for a few minutes on that (usually things fail in the first few seconds if there's a problem) I'll then do much longer tests with something like Prime.
I then tend to run the "Furmark" test that's part of OCCT, that get's my GPU's hotter than anything else does by 5-7c.
If my machine passes these test, I consider it stable, and bump things up again.
Personally, my 2500k is not a good one - a Silicon lottery DNF in effect - as one of it's cores is very poor, and struggles past 4.6ghz. The other cores just keep going to 5 quite happily though, which is frustrating. Still, at "just" 4.5 it does everything I want.
Not sure what else to suggest, but you do need to get back to stock EVERYTHING and test from there. It could be a power issue, it could be that your card is faulty, or maybe it's just one of those cards that won't overclock.
Best of luck.
Scoob.