depends, if you are going to be folding 24/7 it might not be enough, but if you are just using it for normal use and gaming the RX rad will probably cover it. I Have the RS360 and a black ice 120 for my loop with a i7 920 @ 4.2ghz 1.375 vcore and a GTX 480 @ 850mhz. The temps can get up there if I'm putting heavy stress on the system, but it will stick around 70-72.
If you are going to add another another GPU later you might want to go with more rad. That might overpower the system.