I looks like a pretty nice mouse with lots of features, but I can't swallow that cost right now. $150+ for a mouse is a bit too steep, especially considering this is the very first iteration of this design. Perhaps when they work out the bugs, refine the design a little, and drop the price inside $100, maybe I'll make the jump. But until then, my Roccat Tyon works just fine.
Considering most games the mouse is your camera or even your movement direction, having tilt and pitch as away to switch button features would be a hinders I'd think, plus the lifting to fly and keep it dead still and straight while trying to press a mouse button would be interesting. I think it's a sounds good on paper thing