It depends on what you are going to do, games, I would say not a chance unless you like really it jerky if not crawling, desktop and maybe videos, it should handle at a push.
Tom did a video a few months back where he did 4k test on a machine with 2 or 3 780 Ti's if memory serves me correctly (which it probably doesn't), and even on those (which was the top dog card at the time) it wasn't what you could call brilliant performance in gaming.