AMD Threadripper on the Top with a 1080TI card, 10gbe something like a workstation/3d rendering PC and a z370 intel on the bottom as a gaming/streaming pc. Maybe do something so they can share the storage
I think the big wake up call was when AMD released Ryzen and people actually realised "Man, Intel have been ripping me off !!". Most of us worked it out before that, but any one else who needed proof got it.
I voted AMD BBUUUTT I don't think the 64 is a great choice for the main Threadripper part, a 1080Ti would work for it, that being said though a 64 for the ITX part absolutely!
Given the choice I think AMD but the only thing is vega gpu. Like to see you use that 1080ti msi lightning for overkill on the gaming side. That if you still have it floating around