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Old 22-03-12, 03:50 PM
riotcity76 riotcity76 is offline
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Vijay has posted two updates to his blog regarding new folding results:

First, FAH simulations lead to a new therapeutic strategy for Alzheimer's Disease


I'm very excited to finally talk about some key new results from our lab. These results have been a long time in coming and in many ways represents a major achievement for [email protected] (FAH) in general, demonstrating that the approach we started 10 years ago can make significant steps forward in our long term goals.

Specifically, our long term goals have been to 1) develop new methods to tackle the computational challenges of simulating protein folding; 2) apply these methods to gain new insights into protein folding; 3) use these methods and new insights to simulate Aß protein misfolding, a key process in the toxicity of Alzheimer's Disease (AD); and finally 4) to use those simulations to develop new small molecule drug candidates for AD. In the early years of FAH, we concentrated on the first two goals above. In the last 5-7 years, we have worked to accomplish the third goal. I'm now very excited to report our progress on the last goal –– using FAH for the development of new therapeutic strategies for AD.

In a paper just published in the Journal of Medicinal Chemistry, we report on tests of predictions from earlier [email protected] simulations, and how these predictions have led to a new strategy to fight Alzheimer's Disease. While this is not a cure, it is a major step towards our final goal, some light at the end of the tunnel.

The next steps, now underway in our lab, are to take this lead compound and help push it towards a viable drug. It's too early to report on our preliminary results there (I like to only talk publicly about work after it's passed through peer review), I'm very excited that the directions set out in this paper do appear to be bearing fruit in terms of a viable drug (not just a drug candidate). I hope I'll have more to say in the coming months!
Second, Stanford scientists and collaborators boost potency, reduce side effects of IL-2 protein used to treat cancer


Today, I'm highlighting the work primarily out of Chris Garcia's lab at Stanford Medical School. The Garcia lab had a very exciting idea on how to re-engineer a very important protein and the Pande lab played a part by providing computer simulations to help understand the mechanism by which the new protein worked. The results are very exciting. Check out the link below for more details.


SUMMARY. The utility of a naturally occurring protein given, sometimes to great effect, as a drug to treat advanced cancers is limited by the severe side effects it sometimes causes. But a Stanford University School of Medicine scientist has generated a mutant version of the protein whose modified shape renders it substantially more potent than the natural protein while reducing its toxicity.

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Old 22-03-12, 03:53 PM
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hmmblah hmmblah is offline
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Nice to see something come of all of our efforts (besides the delicious points). I really hope they have a viable drug soon.
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Old 22-03-12, 04:15 PM
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jits h jits h is offline
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Nice to see just leaving our rigs and running a program makes a huge difference for many people

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Old 22-03-12, 06:10 PM
Pickster Pickster is offline
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Originally Posted by mini me View Post

Nice to see just leaving our rigs and running a program makes a huge difference for many people
I use to feel a little bad (sometimes) when asked for money for charity by folk on the street.

Now when I'm asked and I tell them I don't have the time, I think to myself that I'm probably doing more for charity than they are.

*Pats self on back*

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