Have done a fair bit of research whilst I am far from an expert I have learnt a fair bit without actually owning one.
You will need a monster WC setup as you must add the wattage of the tec at max load and the cpu at max load (baring in mind anything else in the loop.
Your Tec idealy needs to have a watt rateing with at least 30% headroom left eg your CPU is 100W your gonna need TEC capable of atleast 130w bare minimum.
You are gonna most likely gonna need a aux PSU again capable of powering the TEC again you don't want the PSU to be maxed out when the TEC is.
From what I have heard many PSU's cannot accomodate the TEC due to its power draw/ampage requirements especialy when useign the ''the real peltiers''
Many say the swiftech tec doesn't really cut it, is a very entry level peltier and a good WC is better for the upper end of overclocking, for this pro's are recommending buying a peltier and cooling it with a conventional WC block and of corse insulating it, which in itself was a turn off for me as I liked the idea of the insualtion and a manual
your gonna need lots of di-electric grease for the socket plenty of foam insulation and conformal coating is highly recommended. there is no room for error as I'm sure your aware that if it's not 100% airtight you will get condensation and its game over!!!
All in all I found this far to ''experimental'' and risky myself, and it seemed to be the swiftech peltier just simply wouldn't meet my requirments...many are a little dissapointed.