its gotta be game related maybe it just doent like that huge of a resolution I'd say pump it down to 1080p and be done I play wow at 1080p and never have any issues with playability or fps at all.
2x 240GB Kingston HyperX 3K's in Raid0
WD Black 649Gb 64mb Sata 6GB/s
HIS 7970's in xfire
Custom water Cooled