its gotta be game related maybe it just doent like that huge of a resolution I'd say pump it down to 1080p and be done I play wow at 1080p and never have any issues with playability or fps at all.
Gigabyte GA-Z68X-UD4 Intel Core I7 2600K
2x Kingston Hyper X 3K 240Gb SSD's in Raid0
WD Black 1TB Storage
HIS 7970's in Crossfire
Custom Cooled 420mm & 280mm rads
NZXT Switch 810 Corsair AX850